Mechanisms of Protein Search for Targets on DNA: Theoretical Insights
Name
molecules-23-02106.pdf
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1.18 MB
Format
Adobe PDF
Checksum (MD5)
7aac2f8fd5fc1adccc6a4029bea63685
Author(s)
Kochugaeva, Maria P.
Kolomeisky, Anatoly B.
Shvets, Alexey
Kochugaeva, Maria
Kolomeisky, Anatoly
Date Issued
August 2018
Journal
Molecules
Publisher
MDPI AG
Citation
Shvets, Alexey et al. "Mechanisms of Protein Search for Targets on DNA: Theoretical Insights." Molecules 23, 9 (August 2018): 2106 © 2018 The Authors
Version
Final published version
Abstract
Protein-DNA interactions are critical for the successful functioning of all natural systems. The key role in these interactions is played by processes of protein search for specific sites on DNA. Although it has been studied for many years, only recently microscopic aspects of these processes became more clear. In this work, we present a review on current theoretical understanding of the molecular mechanisms of the protein target search. A comprehensive discrete-state stochastic method to explain the dynamics of the protein search phenomena is introduced and explained. Our theoretical approach utilizes a first-passage analysis and it takes into account the most relevant physical-chemical processes. It is able to describe many fascinating features of the protein search, including unusually high effective association rates, high selectivity and specificity, and the robustness in the presence of crowders and sequence heterogeneity.
MIT Department
Institute for Medical Engineering and Science
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/molecules23092106
