Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives
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Author(s)
McGowan, Meredeth A.
McAvoy, Camille Z.
Buchwald, Stephen Leffler
Date Issued
July 2012
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
McGowan, Meredeth A., Camille Z. McAvoy, and Stephen L. Buchwald. “Palladium-Catalyzed N-Monoarylation of Amidines and a One-Pot Synthesis of Quinazoline Derivatives.” Org. Lett. 14, no. 14 (July 20, 2012): 3800–3803.
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Author's final manuscript
Abstract
A method for the Pd-catalyzed N-arylation of both aryl and alkyl amidines with a wide range of aryl bromides, chlorides, and triflates is described. The reactions proceed in short reaction times and with excellent selectivity for monoarylation. A one-pot synthesis of quinazoline derivatives, via addition of an aldehyde to the crude reaction mixture following Pd-catalyzed N-arylation, is also demonstrated.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ol301700y
