Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration
Name
nihms-1667385.pdf
Description
Accepted version
Size
1.72 MB
Format
Unknown
Checksum (MD5)
2da275b8b08e3314c8d98f153b201818
Author(s)
Scimone, M. Lucila
Atabay, Kutay D
Fincher, Christopher T.
Bonneau, Ashley R
Li, Dayan
Reddien, Peter
Date Issued
2020
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Version
Author's final manuscript
Abstract
© 2020 American Association for the Advancement of Science. All rights reserved. Neuronal circuits damaged or lost after injury can be regenerated in some adult organisms, but the mechanisms enabling this process are largely unknown. We used the planarian Schmidtea mediterranea to study visual system regeneration after injury. We identify a rare population of muscle cells tightly associated with photoreceptor axons at stereotyped positions in both uninjured and regenerating animals. Together with a neuronal population, these cells promote de novo assembly of the visual system in diverse injury and eye transplantation contexts. These muscle guidepost-like cells are specified independently of eyes, and their position is defined by an extrinsic array of positional information cues. These findings provide a mechanism, involving adult formation of guidepost-like cells typically observed in embryos, for axon pattern restoration in regeneration.
MIT Department
Howard Hughes Medical Institute
Whitehead Institute for Biomedical Research
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/SCIENCE.ABA3203
