Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory
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Sarinana-2014-Differential roles o.pdf
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Author(s)
Sarinana, Joshua
Kitamura, Takashi
Kunzler, Patrik
Sultzman, Lisa
Tonegawa, Susumu
Date Issued
May 2014
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Sarinana, Joshua, Takashi Kitamura, Patrik Kunzler, Lisa Sultzman, and Susumu Tonegawa. “Differential Roles of the Dopamine 1-Class Receptors, D1R and D5R, in Hippocampal Dependent Memory.” Proceedings of the National Academy of Sciences 111, no. 22 (May 19, 2014): 8245–8250.
Version
Final published version
Abstract
Pharmacological and global KO studies have worked to elucidate the function of dopamine 1-class receptors (D1Rs and D5Rs) in hippocampal-dependent learning and memory. Yet, these manipulations are unable to restrict D1R from D5R activity within hippocampal subregions. We generated mice that lack D1Rs or D5Rs in dentate gyrus (DG) granule cells of the hippocampus. This allowed us to characterize the precise role of D1Rs and D5Rs in modulating c-Fos activity in the hippocampus and in Pavlovian fear conditioning. We demonstrate that DG D1R deletion, but not D5R deletion, increases DG granule cell baseline c-Fos activity, decreases DG and CA3 c-Fos activity in response to contextual exposure and to contextual fear conditioning, impairs contextual memory formation, and enhances generalization of the conditioned fear response.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1407395111
