SMC complexes link gene expression and genome architecture
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SMC complexes.pdf
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Author(s)
Dowen, Jill M.
Young, Richard A.
Date Issued
May 2014
Journal
Current Opinion in Genetics & Development
Publisher
Elsevier
Citation
Dowen, Jill M., and Richard A. Young. “SMC Complexes Link Gene Expression and Genome Architecture.” Current Opinion in Genetics & Development 25 (April 2014): 131–137.
Version
Author's final manuscript
Abstract
The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture. Among these, we note evidence that SMC complexes play important roles in the regulation of genes that control cell identity. We conclude by reviewing diseases associated with SMC mutations.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.gde.2013.11.009
