Arylation chemistry for bioconjugation
Name
nihms-1014756.pdf
Description
Accepted version
Size
5.42 MB
Format
Adobe PDF
Checksum (MD5)
b9ae3e8854db66db857d9dc62abc59d7
Author(s)
Zhang, Chi
Vinogradova, Ekaterina V.
Spokoyny, Alexander M.
Buchwald, Stephen Leffler
Pentelute, Bradley L.
Date Issued
November 2018
Journal
Angewandte Chemie. International edition in English
Publisher
Wiley
Citation
Zhang, Chi, et al., "Arylation chemistry for bioconjugation." Angewandte Chemie. International edition in English 58, 15 (November 2018): no. 4810 doi 10.1002/ANIE.201806009 ©2018 Author(s)
Version
Author's final manuscript
Abstract
Bioconjugation chemistry has been used to prepare modified biomolecules with functions beyond what nature intended. Central to these techniques is the development of highly efficient and selective bioconjugation reactions that operate under mild, biomolecule compatible conditions. Methods that form a nucleophile–sp 2 carbon bond show promise for creating bioconjugates with new modifications, sometimes resulting in molecules with unparalleled functions. Here we outline and review sulfur, nitrogen, selenium, oxygen, and carbon arylative bioconjugation strategies and their applications to modify peptides, proteins, sugars, and nucleic acids. ©2019
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/ANIE.201806009
