Designs of continuous-flow pharmaceutical crystallizers: developments and practice
Name
c8ce00042e.pdf
Size
6.47 MB
Format
Adobe PDF
Checksum (MD5)
6bb2c1bbb0d5604169df92946ca8b215
Author(s)
Jiang, Mo
Braatz, Richard D.
Date Issued
April 29, 2019
Journal
CrystEngComm
Publisher
Royal Society of Chemistry (RSC)
Citation
Jiang, Mo, and Richard D. Braatz. “Designs of Continuous-Flow Pharmaceutical Crystallizers: Developments and Practice.” CrystEngComm 21, no. 23 (2019): 3534–51. © 2019 The Royal Society of Chemistry
Version
Final published version
Abstract
Crystallization is an effective, low-cost purification & formulation process widely applied to pharmaceuticals
and fine chemicals. This review describes recent advances in research on lab-scale solution-based continuous crystallization, including (1) a 5-step general design procedure; (2) key design/operational parameters;
(3) process intensification strategies; and (4) a case study. The continuous crystallizers reviewed include
mixed-suspension mixed-product removal, fluidized beds, oscillatory baffled flow, and tubular laminar/segmented/slug-flow crystallizers. Their corresponding design and operational considerations are summarized in terms of general parameters (e.g., residence time), and crystallizer-specific parameters and strategies (e.g., mixing strategies). In-line nucleation and crystal modification methods are categorized, including use
of micromixers, wet milling, ultrasonication, temperature cycling, and recycling selection (filtration, sedimentation). Throughout the article, links are drawn with extensive existing knowledge of batch crystallizers,
to facilitate the understanding and design of continuous crystallizers.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution Noncommercial 3.0 unported license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/c8ce00042e
