Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation
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Bear-Loss of Arc renders.pdf
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Author(s)
McCurry, Cortina L.
Shepherd, Jason Dennis
Tropea, Daniela
Wang, Kuan H.
Bear, Mark
Sur, Mriganka
Date Issued
April 2010
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
McCurry, Cortina L. et al. “Loss of Arc Renders the Visual Cortex Impervious to the Effects of Sensory Experience or Deprivation.” Nature Neuroscience 13.4 (2010): 450–457.
Version
Author's final manuscript
Abstract
A myriad of mechanisms have been suggested to account for the full richness of visual cortical plasticity. We found that visual cortex lacking Arc is impervious to the effects of deprivation or experience. Using intrinsic signal imaging and chronic visually evoked potential recordings, we found that Arc−/− mice did not exhibit depression of deprived-eye responses or a shift in ocular dominance after brief monocular deprivation. Extended deprivation also failed to elicit a shift in ocular dominance or open-eye potentiation. Moreover, Arc−/− mice lacked stimulus-selective response potentiation. Although Arc−/− mice exhibited normal visual acuity, baseline ocular dominance was abnormal and resembled that observed after dark-rearing. These data suggest that Arc is required for the experience-dependent processes that normally establish and modify synaptic connections in visual cortex.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/nn.2508
