Multiphoton autofluorescence imaging of advanced glycation end products in glycated tissues
Name
112441V.pdf
Description
Published version
Size
685.39 KB
Format
Unknown
Checksum (MD5)
99b211d7595a056ca221198ae08c9fea
Author(s)
Lin, Chih-Ju
Kang, Jeon Woong
So, Peter T. C.
Dong, Chen-Yuan
Date Issued
February 2020
Journal
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Publisher
SPIE
Citation
Lin, Chih-Ju, Kang, Jeon Woong, So, Peter T. C. and Dong, Chen-Yuan. 2020. "Multiphoton autofluorescence imaging of advanced glycation end products in glycated tissues." Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 11244.
Version
Final published version
Abstract
© 2020 SPIE. The formation and accumulation of advanced glycation end products (AGEs) contribute to diabetic complications such as retinopathy, neuropathy, nephropathy, and cardiovascular diseases. It is clear that the development of effective technique in AGEs detection and the establishing the correlation of measured AGE parameters to diabetic pathogenesis are invaluable in the monitoring of disease progression and drug discovery of anti-AGE compounds. Since some AGE are fluorescent, we propose to investigate the degree of tissue glycation in forming fluorescent AGEs (fAGEs). In this preliminary study, we will investigate the effects of glucose, fructose, and galactose, three of the most abundant dietary simple sugars, in fAGEs production. Excised tissues will be treated in solutions containing the three sugar types; multiphoton autofluorescence imaging will then be performed on the treated tissues to determine their autofluroescence levels.
MIT Department
Massachusetts Institute of Technology. Laser Biomedical Research Center
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1117/12.2545548
