Role of “Western Diet” in Inflammatory Autoimmune Diseases
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11882_2013_Article_404.pdf
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Author(s)
Manzel, Arndt
Muller, Dominik N.
Hafler, David A.
Linker, Ralf A.
Kleinewietfeld, Markus
Erdman, Susan E
Date Issued
December 2013
Journal
Current Allergy and Asthma Reports
Publisher
Springer Science+Business Media
Citation
Manzel, Arndt et al. “Role of ‘Western Diet’ in Inflammatory Autoimmune Diseases.” Current Allergy and Asthma Reports 14.1, Article 404 (2014): p.1-8.
Version
Author's final manuscript
Abstract
Developed societies, although having successfully reduced the burden of infectious disease, constitute an environment where metabolic, cardiovascular, and autoimmune diseases thrive. Living in westernized countries has not fundamentally changed the genetic basis on which these diseases emerge, but has strong impact on lifestyle and pathogen exposure. In particular, nutritional patterns collectively termed the “Western diet”, including high-fat and cholesterol, high-protein, high-sugar, and excess salt intake, as well as frequent consumption of processed and ‘fast foods’, promote obesity, metabolic syndrome, and cardiovascular disease. These factors have also gained high interest as possible promoters of autoimmune diseases. Underlying metabolic and immunologic mechanisms are currently being intensively explored. This review discusses the current knowledge relative to the association of “Western diet” with autoimmunity, and highlights the role of T cells as central players linking dietary influences to autoimmune pathology.
MIT Department
Massachusetts Institute of Technology. Division of Comparative Medicine
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s11882-013-0404-6
