Molecular origin of strain softening in cross-linked F-actin networks
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Lee-2010-Molecular origin of.pdf
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Author(s)
Ferrer, Jorge M.
Lang, Matthew J.
Kamm, Roger Dale
Lee, Hyungsuk
Date Issued
July 2010
Journal
Physical Review E
Publisher
American Physical Society
Citation
Lee, Hyungsuk et al. “Molecular origin of strain softening in cross-linked F-actin networks.” Physical Review E 82.1 (2010): 011919. © 2010 The American Physical Society.
Version
Final published version
Abstract
Two types of measurement are presented that relate molecular events to macroscopic behavior of F-actin networks. First, shear modulus is measured by oscillating an embedded microbead. Second, a microbead is translated at constant rate and transitions in the resisting force are observed. The loading rate dependence of the force at the transitions is similar to that of the molecular unbinding force, suggesting that they share a common origin. Reversibility tests of shear modulus provide further evidence that strain softening of F-actin networks is caused by force-induced rupture of cross-links.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1103/PhysRevE.82.011919
