Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice
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Xuan-2014-Transcranial low-lev.pdf
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Author(s)
Xuan, Weijun
Vatansever, Fatma
Huang, Liyi
Hamblin, Michael R.
Date Issued
October 2014
Journal
Journal of Biomedical Optics
Publisher
SPIE
Citation
Xuan, Weijun, Fatma Vatansever, Liyi Huang, and Michael R. Hamblin. “Transcranial Low-Level Laser Therapy Enhances Learning, Memory, and Neuroprogenitor Cells after Traumatic Brain Injury in Mice.” Journal of Biomedical Optics 19, no. 10 (October 1, 2014): 108003. © 2014 Society of Photo-Optical Instrumentation Engineers
Version
Final published version
Abstract
The use of transcranial low-level laser (light) therapy (tLLLT) to treat stroke and traumatic brain injury (TBI) is attracting increasing attention. We previously showed that LLLT using an 810-nm laser 4 h after controlled cortical impact (CCI)-TBI in mice could significantly improve the neurological severity score, decrease lesion volume, and reduce Fluoro-Jade staining for degenerating neurons. We obtained some evidence for neurogenesis in the region of the lesion. We now tested the hypothesis that tLLLT can improve performance on the Morris water maze (MWM, learning, and memory) and increase neurogenesis in the hippocampus and subventricular zone (SVZ) after CCI-TBI in mice. One and (to a greater extent) three daily laser treatments commencing 4-h post-TBI improved neurological performance as measured by wire grip and motion test especially at 3 and 4 weeks post-TBI. Improvements in visible and hidden platform latency and probe tests in MWM were seen at 4 weeks. Caspase-3 expression was lower in the lesion region at 4 days post-TBI. Double-stained BrdU-NeuN (neuroprogenitor cells) was increased in the dentate gyrus and SVZ. Increases in double-cortin (DCX) and TUJ-1 were also seen. Our study results suggest that tLLLT may improve TBI both by reducing cell death in the lesion and by stimulating neurogenesis.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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DOI of Published Version
https://doi.org/10.1117/1.jbo.19.10.108003
