DCTclock: Clinically-Interpretable and Automated Artificial Intelligence Analysis of Drawing Behavior for Capturing Cognition
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fdgth-03-750661.pdf
Description
Published version
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804.4 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Souillard-Mandar, William
Penney, Dana
Schaible, Braydon
Pascual-Leone, Alvaro
Au, Rhoda
Davis, Randall
Date Issued
2021
Journal
Frontiers in Digital Health
Publisher
Frontiers Media SA
Citation
Souillard-Mandar, William, Penney, Dana, Schaible, Braydon, Pascual-Leone, Alvaro, Au, Rhoda et al. 2021. "DCTclock: Clinically-Interpretable and Automated Artificial Intelligence Analysis of Drawing Behavior for Capturing Cognition." Frontiers in Digital Health, 3.
Version
Final published version
Abstract
Developing tools for efficiently measuring cognitive change specifically and brain health generally—whether for clinical use or as endpoints in clinical trials—is a major challenge, particularly for conditions such as Alzheimer's disease. Technology such as connected devices and advances in artificial intelligence offer the possibility of creating and deploying clinical-grade tools with high sensitivity, rapidly, cheaply, and non-intrusively. Starting from a widely-used paper and pencil cognitive status test—The Clock Drawing Test—we combined a digital input device to capture time-stamped drawing coordinates with a machine learning analysis of drawing behavior to create DCTclock™, an automated analysis of nuances in cognitive performance beyond successful task completion. Development and validation was conducted on a dataset of 1,833 presumed cognitively unimpaired and clinically diagnosed cognitively impaired individuals with varied neurological conditions. We benchmarked DCTclock against existing clock scoring systems and the Mini-Mental Status Examination, a widely-used but lengthier cognitive test, and showed that DCTclock offered a significant improvement in the detection of early cognitive impairment and the ability to characterize individuals along the Alzheimer's disease trajectory. This offers an example of a robust framework for creating digital biomarkers that can be used clinically and in research for assessing neurological function.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.3389/FDGTH.2021.750661
