Rapamycin inhibits mTORC1, but not completely
Name
Sabatini_Rapamycin inhibits.pdf
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585.97 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Thoreen, Carson C
Sabatini, David
Date Issued
July 2009
Journal
Autophagy
Publisher
Landes Bioscience
Citation
Thoreen, Carson C., and David M. Sabatini. “Rapamycin Inhibits mTORC1, but Not Completely.” Autophagy 5.5 (2009): 725–727. © 2009 Landes Bioscience
Version
Final published version
Abstract
Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.4161/auto.5.5.8504
