Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers
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1610.00183.pdf
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Author(s)
Varilly, Patrick
Willard, Adam P.
Kirkegaard, Julius B.
Knowles, Tuomas P. J.
Chandler, David
Date Issued
April 2017
Journal
The Journal of Chemical Physics
Publisher
American Institute of Physics (AIP)
Citation
Varilly, Patrick et al. “Intra-Chain Organisation of Hydrophobic Residues Controls Inter-Chain Aggregation Rates of Amphiphilic Polymers.” The Journal of Chemical Physics 146, 13 (April 2017): 135102 © 2017 Author(s)
Version
Original manuscript
Abstract
Aggregation of amphiphiles through the action of hydrophobic interactions is a common feature in soft condensed matter systems and is of particular importance in the context of biophysics as it underlies both the generation of functional biological machinery as well as the formation of pathological misassembled states of proteins. Here we explore the aggregation behaviour of amphiphilic polymers using lattice Monte Carlo calculations and show that the distribution of hydrophobic residues within the polymer sequence determines the facility with which dry/wet interfaces can be created and that such interfaces drive the aggregation process.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1063/1.4977932
