Memory, plasticity, and sleep – a role for calcium permeable AMPA receptors?
Name
Shepherd-2012-Memory, plasticity, and sleep.pdf
Size
1.49 MB
Format
Adobe PDF
Checksum (MD5)
8f8ee766b96b776c4bb8c0a702a54af9
Author(s)
Shepherd, Jason Dennis
Date Issued
April 2012
Journal
Frontiers in Molecular Neuroscience
Publisher
Frontiers Research Foundation
Citation
Shepherd, Jason D. “Memory, Plasticity and Sleep - A Role for Calcium Permeable AMPA Receptors?” Frontiers in Molecular Neuroscience 5 (2012).
Version
Final published version
Abstract
Experience shapes and molds the brain throughout life.These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter release or through neurotransmitter detection at synapses. The predominant neurotransmitter receptor in excitatory transmission, the AMPA-type glutamate receptor (AMPAR), is exquisitely sensitive to changes in experience and synaptic activity. These ion channels are usually impermeable to calcium, a property conferred by the GluA2 subunit. However, GluA2-lacking AMPARs are permeable to calcium and have recently been shown to play a unique role in synaptic function. In this review, I will describe new findings on the role of calcium permeable AMPARs (CP-AMPARs) in experience-dependent and synaptic plasticity.These studies suggest that CP-AMPARs play a prominent role in maintaining circuits in a labile state where further plasticity can occur, thus promoting metaplasticity. Moreover, the abnormal expression of CP-AMPARs has been implicated in drug addiction and memory disorders and thus may be a novel therapeutic target.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fnmol.2012.00049
