Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization
Name
nihms-976382.pdf
Description
Accepted version
Size
2.01 MB
Format
Adobe PDF
Checksum (MD5)
f750d474ddef576e72b7cf2488d0fa53
Author(s)
Kelly, Sean M
Raudales, Ricardo
He, Miao
Lee, Jannifer H
Kim, Yongsoo
Gibb, Leif G
Wu, Priscilla
Matho, Katherine
Osten, Pavel
Graybiel, Ann M
Date Issued
2018
Journal
Neuron
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2018 Elsevier Inc. The circuitry of the striatum is characterized by two organizational plans: the division into striosome and matrix compartments, thought to mediate evaluation and action, and the direct and indirect pathways, thought to promote or suppress behavior. The developmental origins of these organizations and their developmental relationships are unknown, leaving a conceptual gap in understanding the cortico-basal ganglia system. Through genetic fate mapping, we demonstrate that striosome-matrix compartmentalization arises from a lineage program embedded in lateral ganglionic eminence radial glial progenitors mediating neurogenesis through two distinct types of intermediate progenitors (IPs). The early phase of this program produces striosomal spiny projection neurons (SPNs) through fate-restricted apical IPs (aIP S s) with limited capacity; the late phase produces matrix SPNs through fate-restricted basal IPs (bIP M s) with expanded capacity. Notably, direct and indirect pathway SPNs arise within both aIP S and bIP M pools, suggesting that striosome-matrix architecture is the fundamental organizational plan of basal ganglia circuitry. In this article, Kelly et al. describe a lineage program embedded in lateral ganglionic eminence progenitors responsible for striosome-matrix compartmentalization in striatum.
MIT Department
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.NEURON.2018.06.021
