Fragile X mental retardation protein and synaptic plasticity
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1756-6606-6-15.pdf
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421.94 KB
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Adobe PDF
Checksum (MD5)
981e940f54d1ee32c43e7753fc8decf0
Author(s)
Sidorov, Michael Samuel
Auerbach, Benjamin David
Bear, Mark
Date Issued
April 2013
Journal
Molecular Brain
Publisher
BioMed Central Ltd
Citation
Sidorov, Michael S, Benjamin D Auerbach, and Mark F Bear. “Fragile X Mental Retardation Protein and Synaptic Plasticity.” Molecular Brain 6.1 (2013): 15.
Version
Final published version
Abstract
Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1186/1756-6606-6-15
