Engineered Livers for Infectious Diseases
Name
1-s2.0-S2352345X17301601-main.pdf
Description
Published version
Size
927.55 KB
Format
Adobe PDF
Checksum (MD5)
cbba188e5202cb7bf8c75912348cdeaa
Author(s)
Gural, Nil
Mancio Silva, Liliana
He, Jiang
Bhatia, Sangeeta N
Date Issued
November 2017
Journal
Cellular and Molecular Gastroenterology and Hepatology
Publisher
Elsevier BV
Citation
Gural, Nil et al. "Engineered Livers for Infectious Diseases." Cellular and Molecular Gastroenterology and Hepatology 5, 2 (January 2018): P131-144 © 2018 The Authors
Version
Final published version
Abstract
Engineered liver systems come in a variety of platform models, from 2-dimensional cocultures of primary human hepatocytes and stem cell–derived progeny, to 3-dimensional organoids and humanized mice. Because of the species-specificity of many human hepatropic pathogens, these engineered systems have been essential tools for biologic discovery and therapeutic agent development in the context of liver-dependent infectious diseases. Although improvement of existing models is always beneficial, and the addition of a robust immune component is a particular need, at present, considerable progress has been made using this combination of research platforms. We highlight advances in the study of hepatitis B and C viruses and malaria-causing Plasmodium falciparum and Plasmodium vivax parasites, and underscore the importance of pairing the most appropriate model system and readout modality with the particular experimental question at hand, without always requiring a platform that recapitulates human physiology in its entirety.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.jcmgh.2017.11.005
