The Structure Inventory of the Nuclear Pore Complex
Name
nihms778076.pdf
Size
1.01 MB
Format
Adobe PDF
Checksum (MD5)
738e9e894963d68ae1e1c796101b7e59
Author(s)
Schwartz, Thomas
Date Issued
March 2016
Journal
Journal of Molecular Biology
Publisher
Elsevier
Citation
Schwartz, Thomas U. “The Structure Inventory of the Nuclear Pore Complex.” Journal of Molecular Biology 428, 10 (May 2016): 1986–2000 © 2016 Elsevier Ltd
Version
Author's final manuscript
Abstract
The nuclear pore complex (NPC) is the principal gateway for molecular exchange between nucleus and cytoplasm across the nuclear envelope. Due to its sheer size of estimated 50-112 MDa and its complex buildup from about 500-1000 individual proteins, it is a difficult object to study for structural biologists. Here, I review the extensive ensemble of high-resolution structures of the building blocks of the NPC. Concurrent with the increase in size and complexity, these latest, large structures and assemblies can now be used as the basis for hybrid approaches, primarily in combination with cryo-electron microscopic analysis, generating the first structure-based assembly models of the NPC. Going forward, the structures will be critically important for a detailed analysis of the NPC, including function, evolution, and assembly. Keywords: macromolecular complexes; nuclear pore complex
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.JMB.2016.03.015
