Relative contribution of feedforward excitatory connections to ocular dominance plasticity in layer 4 of visual cortex
Name
Bear-2010-Relative contribution.pdf
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1.83 MB
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Author(s)
Khibnik, Lena A.
Cho, Kathleen K.
Date Issued
May 2010
Journal
Neuron
Publisher
Elsevier B.V.
Citation
Khibnik, Lena A., Kathleen K.A. Cho, and Mark F. Bear. “Relative Contribution of Feedforward Excitatory Connections to Expression of Ocular Dominance Plasticity in Layer 4 of Visual Cortex.” Neuron 66.4 (2010): 493–500.
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Author's final manuscript
Abstract
Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmission. An OD shift was first induced with 3 days of MD, and then the influences of intracortical polysynaptic inhibitory and excitatory synapses were pharmacologically removed, leaving only “feedforward” thalamocortical synaptic currents. The results show that the rapid OD shift following MD is strongly expressed at the level of thalamocortical synaptic transmission.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2010.04.012
