Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth
Name
nihms484495.pdf
Description
Accepted version
Size
1.69 MB
Format
Adobe PDF
Checksum (MD5)
88916d9e93b061816458431e6f81f69f
Author(s)
Shah, Nisarg J.
Hong, Jinkee
Hyder, Md Nasim
Hammond, Paula T
Date Issued
March 2012
Journal
Advanced Materials
Publisher
Wiley
Citation
Shah, Nisarg J. et al., "Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth." Advanced Materials 24, 11 (March 2012): 1445-50 doi. 10.1002/adma.201104475 ©2012 Authors
Version
Author's final manuscript
Abstract
Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants. Copyright ©2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adma.201104475
