Molecular Magnetic Resonance Imaging of Tumor Response to Therapy
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Shuhendler_Molecular magnetic.pdf
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Author(s)
Shuhendler, Adam J.
Ye, Deju
Brewer, Kimberly D.
Bazalova-Carter, Magdalena
Lee, Kyung-Hyun
Kempen, Paul
Graves, Edward E.
Rutt, Brian
Rao, Jianghong
Wittrup, Karl Dane
Date Issued
October 2015
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Shuhendler, Adam J., Deju Ye, Kimberly D. Brewer, Magdalena Bazalova-Carter, Kyung-Hyun Lee, Paul Kempen, K. Dane Wittrup, Edward E. Graves, Brian Rutt, and Jianghong Rao. “Molecular Magnetic Resonance Imaging of Tumor Response to Therapy.” Scientific Reports 5 (October 6, 2015): 14759.
Version
Final published version
Abstract
Personalized cancer medicine requires measurement of therapeutic efficacy as early as possible, which is optimally achieved by three-dimensional imaging given the heterogeneity of cancer. Magnetic resonance imaging (MRI) can obtain images of both anatomy and cellular responses, if acquired with a molecular imaging contrast agent. The poor sensitivity of MRI has limited the development of activatable molecular MR contrast agents. To overcome this limitation of molecular MRI, a novel implementation of our caspase-3-sensitive nanoaggregation MRI (C-SNAM) contrast agent is reported. C-SNAM is triggered to self-assemble into nanoparticles in apoptotic tumor cells, and effectively amplifies molecular level changes through nanoaggregation, enhancing tissue retention and spin-lattice relaxivity. At one-tenth the current clinical dose of contrast agent, and following a single imaging session, C-SNAM MRI accurately measured the response of tumors to either metronomic chemotherapy or radiation therapy, where the degree of signal enhancement is prognostic of long-term therapeutic efficacy. Importantly, C-SNAM is inert to immune activation, permitting radiation therapy monitoring.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1038/srep14759
