Transperineal prostate biopsy: analysis of a uniform core sampling pattern that yields data on tumor volume limits in negative biopsies
Name
Kepner-2010-Transperineal prostate biopsy.pdf
Size
2.11 MB
Format
Adobe PDF
Checksum (MD5)
8e38c61c66d3b78a272ebc9813799e4c
Author(s)
Kepner, Gordon R.
Kepner, Jeremy
Date Issued
June 2010
Journal
Theoretical Biology and Medical Modelling
Publisher
BioMed Central Ltd.
Citation
Kepner, Gordon R., and Jeremy V. Kepner. “Transperineal Prostate Biopsy: Analysis of a Uniform Core Sampling Pattern That Yields Data on Tumor Volume Limits in Negative Biopsies.” Theoretical Biology and Medical Modelling 7.23 (2010): 1-13.
Version
Final published version
Abstract
Background
Analyze an approach to distributing transperineal prostate biopsy cores that yields data on the volume of a tumor that might be present when the biopsy is negative, and also increases detection efficiency.
Methods
Basic principles of sampling and probability theory are employed to analyze a transperineal biopsy pattern that uses evenly-spaced parallel cores in order to extract quantitative data on the volume of a small spherical tumor that could potentially be present, even though the biopsy did not detect it, i.e., negative biopsy.
Results
This approach to distributing biopsy cores provides data for the upper limit on the volume of a small, spherical tumor that might be present, and the probability of smaller volumes, when biopsies are negative and provides a quantitative basis for evaluating the effectiveness of different core spacing distances.
Conclusions
Distributing transperineal biopsy cores so they are evenly spaced provides a means to calculate the probability that a tumor of given volume could be present when the biopsy is negative, and can improve detection efficiency.
MIT Department
Lincoln Laboratory
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1186/1742-4682-7-23
