Distributed Coding of Evidence Accumulation across the Mouse Brain Using Microcircuits with a Diversity of Timescales
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ENEURO.0282-23.2023.full.pdf
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Author(s)
Imani, Elaheh
Radkani, Setayesh
Hashemi, Alireza
Harati, Ahad
Pourreza, Hamidreza
Goudarzi, Morteza
Date Issued
October 20, 2023
Journal
eNeuro
Publisher
Society for Neuroscience
Citation
Elaheh Imani, Setayesh Radkani, Alireza Hashemi, Ahad Harati, Hamidreza Pourreza, Morteza Moazami Goudarzi, eNeuro 20 October 2023, 10 (11) ENEURO.0282-23.2023.
Version
Final published version
Abstract
The gradual accumulation of noisy evidence for or against options is the main step in the perceptual decisionmaking process. Using brain-wide electrophysiological recording in mice (Steinmetz et al., 2019), we examined neural correlates of evidence accumulation across brain areas. We demonstrated that the neurons with driftdiffusion model (DDM)-like firing rate activity (i.e., evidence-sensitive ramping firing rate) were distributed across the brain. Exploring the underlying neural mechanism of evidence accumulation for the DDM-like neurons revealed different accumulation mechanisms (i.e., single and race) both within and across the brain areas. Our findings support the hypothesis that evidence accumulation is happening through multiple integration mechanisms in the brain. We further explored the timescale of the integration process in the single and race accumulator models. The results demonstrated that the accumulator microcircuits within each brain area had distinct properties in terms of their integration timescale, which were organized hierarchically across the brain. These findings support the existence of evidence accumulation over multiple timescales. Besides the variability of integration timescale across the brain, a heterogeneity of timescales was observed within each brain area as well. We demonstrated that this variability reflected the diversity of microcircuit parameters, such that accumulators with longer integration timescales had higher recurrent excitation strength.
Subjects
accumulation mechanism
evidence accumulation
integration timescale
perceptual decision making Significance Statement
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1523/ENEURO.0282-23.2023
