Polycomb Group Proteins Set the Stage for Early Lineage Commitment
Name
Boyer_Polycomb group.pdf
Size
1.91 MB
Format
Adobe PDF
Checksum (MD5)
37929bdaa8bee7cd05c8496781fa86d2
Author(s)
Surface, Lauren Elizabeth
Thornton, Seraphim R.
Boyer, Laurie Ann
Date Issued
September 2010
Journal
Cell Stem Cell
Publisher
Elsevier B.V.
Citation
Surface, Lauren E., Seraphim R. Thornton, and Laurie A. Boyer. “Polycomb Group Proteins Set the Stage for Early Lineage Commitment.” Cell Stem Cell 7, no. 3 (September 2010): 288-298. © 2010 Elsevier Inc.
Version
Final published version
Abstract
Precise control of gene expression patterns is critical for the specification of cellular diversity during metazoan development. Polycomb group (PcG) proteins comprise a class of transcriptional modifiers that have dynamic and essential roles in regulating a number of key processes including lineage commitment. How this is accomplished during mammalian development is incompletely understood. Here, we discuss recent studies in embryonic stem cells (ESCs) that provide critical new insights into how PcG proteins may be targeted to genomic sites as well as the mechanisms by which these regulators influence gene expression and multilineage differentiation in mammals.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.stem.2010.08.004
