Design of robust metabolic pathways
Name
122-yp468-Nicosia.pdf
Size
909.08 KB
Format
Adobe PDF
Checksum (MD5)
b0dbd1df4ae44ac2ef05872a01ed08f3
Author(s)
Umeton, Renato
Stracquadanio, Giovanni
Sorathiya, Anilkumar
Papini, Alessio
Nicosia, Giuseppe
Lio, Pietro
Date Issued
June 2011
Journal
Proceedings of the 48th Design Automation Conference on (DAC '11)
Publisher
Association for Computing Machinery (ACM)
Citation
Renato Umeton, Giovanni Stracquadanio, Anilkumar Sorathiya, Pietro Liò, Alessio Papini, and Giuseppe Nicosia. 2011. Design of robust metabolic pathways. In Proceedings of the 48th Design Automation Conference (DAC '11). ACM, New York, NY, USA, 747-752.
Version
Author's final manuscript
Abstract
In this paper we investigate plant photosynthesis and microbial fuel cells. We report the following: 1) we introduce and validate a novel multi-objective optimization algorithm, PMO2; 2) in photosynthesis we increase the yield of 135%, while in Geobacter sulfurreducens we determine the tradeoff for growth versus redox properties; 3) finally, we discuss Pareto-Front as an estimator of robust metabolic pathways.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1145/2024724.2024892
