Metagenomic biomarker discovery and explanation
Name
Segata-2011-Metagenomic biomarker discovery and explanation.pdf
Size
6.92 MB
Format
Adobe PDF
Checksum (MD5)
dcd59f3e22b59c273d27f2f29611768f
Author(s)
Segata, Nicola
Izard, Jacques
Waldron, Levi
Gevers, Dirk
Miropolsky, Larisa
Garrett, Wendy S.
Huttenhower, Curtis
Date Issued
June 2011
Journal
Genome Biology
Publisher
Springer (Biomed Central Ltd.)
Citation
Segata, Nicola et al. “Metagenomic Biomarker Discovery and Explanation.” Genome Biology 12.6 (2011): R60. Web.
Version
Final published version
Abstract
This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1186/gb-2011-12-6-r60
