Metabolomics in cancer research and emerging applications in clinical oncology
Name
caac.21670-1.pdf
Description
Published version
Size
661.63 KB
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Unknown
Checksum (MD5)
52368d91be055be8ce132c98ee6894fe
Author(s)
Schmidt, Daniel R
Patel, Rutulkumar
Kirsch, David G
Lewis, Caroline A
Vander Heiden, Matthew G
Locasale, Jason W
Date Issued
May 2021
Journal
Ca-A Cancer Journal for Clinicians
Publisher
Wiley
Version
Final published version
Abstract
Cancer has myriad effects on metabolism that include both rewiring of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment, and changes in normal tissue metabolism. With the recognition that fluorodeoxyglucose-positron emission tomography imaging is an important tool for the management of many cancers, other metabolites in biological samples have been in the spotlight for cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecule metabolites that like other -omics technologies can provide critical information about the cancer state that are otherwise not apparent. Here, the authors review how cancer and cancer therapies interact with metabolism at the cellular and systemic levels. An overview of metabolomics is provided with a focus on currently available technologies and how they have been applied in the clinical and translational research setting. The authors also discuss how metabolomics could be further leveraged in the future to improve the management of patients with cancer.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3322/caac.21670
