Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media
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Buchwald_Mild palladium.pdf
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Author(s)
Cohen, Daniel Tzvi
Buchwald, Stephen Leffler
Date Issued
January 2015
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Cohen, Daniel T., and Stephen L. Buchwald. “Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media.” Organic Letters 17, 2 (January 2015): 202–205 © 2015 American Chemical Society
Version
Final published version
Abstract
A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)aryl halides and triflates at 2–5 mol % catalyst loadings with temperatures ranging from rt to 40 °C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ol5032359
