Structural advances in transcription elongation
Name
nihms-1825452.pdf
Description
Accepted version
Size
892.59 KB
Format
Adobe PDF
Checksum (MD5)
c3af61494207dcf496524e2e9e718ccd
Author(s)
Mohamed, Abdallah A
Vazquez Nunez, Roberto
Vos, Seychelle M
Date Issued
August 2022
Journal
Current Opinion in Structural Biology
Publisher
Elsevier BV
Citation
Mohamed, Abdallah A, Vazquez Nunez, Roberto and Vos, Seychelle M. 2022. "Structural advances in transcription elongation." Current Opinion in Structural Biology, 75.
Version
Author's final manuscript
Abstract
Transcription is the first step of gene expression and involves RNA polymerases. After transcription initiation, RNA polymerase enters elongation followed by transcription termination at the end of the gene. Only recently, structures of transcription elongation complexes bound to key transcription elongation factors have been determined in bacterial and eukaryotic systems. These structures have revealed numerous insights including the basis for transcriptional pausing, RNA polymerase interaction with large complexes such as the ribosome and the spliceosome, and the transition into productive elongation. Here, we review these structures and describe areas for future research.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.sbi.2022.102422
