INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY
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Author(s)
Judson, Christopher H
Vuong, Laurel N.
Gorczynska, Iwona M
Srinivasan, Vivek J.
Fujimoto, James G
Duker, Jay S
Date Issued
January 2011
Journal
Retinal Cases & Brief Reports
Publisher
Ovid Technologies (Wolters Kluwer Health)
Citation
Judson, Christopher H et al. “INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY.” Retinal Cases & Brief Reports 5.1 (2011): 46-48.
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Author's final manuscript
Abstract
Purpose—To report on a posterior segment coloboma manifesting unusual morphology as
determined by high-speed, ultrahigh resolution optical coherence tomography imaging (hsUHROCT).
Methods—A 47-year-old patient with bilateral colobomas was evaluated via fundus examination
and hsUHR-OCT.
Results—Imaging with hsUHR-OCT showed intact retinal pigment epithelium (RPE) within the
posterior segment coloboma. Most of the retinal layers appeared to continue into the coloboma,
although they exhibited slight attenuation. The external limiting membrane (ELM) was clearly
visible continuing within the coloboma, suggesting that Muller cells and the inner segments of the
photoreceptors were still present in this area. The junction between the inner and outer segments
of the photoreceptors ended at the margin of the coloboma, which may be due to either
photoreceptor disruption or a change in the orientation of the outer segments.
Conclusion—hsUHR-OCT demonstrated the presence of Muller cells and photoreceptor inner
segments within a posterior segment coloboma. The retinal pigment epithelium (RPE) was intact
within the coloboma, representing an unusual morphology.
MIT Department
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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DOI of Published Version
https://doi.org/10.1097/icb.0b013e3181cafc49
