Closed-loop functional optogenetic stimulation
Name
s41467-018-07721-w.pdf
Size
1.43 MB
Format
Adobe PDF
Checksum (MD5)
15c12191d3c5aded7a1d07f34628b459
Author(s)
Srinivasan, Shriya S
Maimon, Benjamin E
Diaz, Maurizio
Song, Hyungeun
Herr, Hugh M
Date Issued
2018
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Citation
Srinivasan, Shriya S., Benjamin E. Maimon, Maurizio Diaz, Hyungeun Song, and Hugh M. Herr. “Closed-Loop Functional Optogenetic Stimulation.” Nature Communications 9, no. 1 (December 2018). doi:10.1038/s41467-018-07721-w.
Version
Final published version
Abstract
© 2018, The Author(s). Optogenetics has been used to orchestrate temporal- and tissue-specific control of neural tissues and offers a wealth of unique advantages for neuromuscular control. Here, we establish a closed-loop functional optogenetic stimulation (CL-FOS) system to control ankle joint position in murine models. Using the measurement of either joint angle or fascicle length as a feedback signal, we compare the controllability of CL-FOS to closed-loop functional electrical stimulation (CL-FES) and demonstrate significantly greater accuracy, lower rise times and lower overshoot percentages. We demonstrate orderly recruitment of motor units and reduced fatigue when performing cyclical movements with CL-FOS compared with CL-FES. We develop and investigate a 3-phase, photo-kinetic model to elucidate the underlying mechanisms for temporal variations in optogenetically activated neuromusculature during closed-loop control experiments. Methods and insights from this study lay the groundwork for the development of closed-loop optogenetic neuromuscular stimulation therapies and devices for peripheral limb control.
MIT Department
Massachusetts Institute of Technology. Media Laboratory
Massachusetts Institute of Technology. Center for Extreme Bionics
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/s41467-018-07721-w
