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Working Memory Load Modulates Neuronal Coupling
Name
bhy065.pdf
Description
Published version
Size
1.07 MB
Format
Adobe PDF
Checksum (MD5)
c9b97e38b87e83d40d7dd2a41f98d209
Author(s)
Pinotsis, Dimitris A
Buschman, Timothy J
Miller, Earl K
Date Issued
2019
Journal
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Version
Final published version
Abstract
© 2018 Published by Oxford University Press. There is a severe limitation in the number of items that can be held in working memory. However, the neurophysiological limits remain unknown. We asked whether the capacity limit might be explained by differences in neuronal coupling. We developed a theoretical model based on Predictive Coding and used it to analyze Cross Spectral Density data from the prefrontal cortex (PFC), frontal eye fields (FEF), and lateral intraparietal area (LIP). Monkeys performed a change detection task. The number of objects that had to be remembered (memory load) was varied (1-3 objects in the same visual hemifield). Changes in memory load changed the connectivity in the PFC-FEF-LIP network. Feedback (top-down) coupling broke down when the number of objects exceeded cognitive capacity. Thus, impaired behavioral performance coincided with a break-down of Prediction signals. This provides new insights into the neuronal underpinnings of cognitive capacity and how coupling in a distributed working memory network is affected by memory load.
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
10.1093/CERCOR/BHY065
