Can nanotechnology potentiate photodynamic therapy?
Name
Huang-2012-Can nanotechnology p.pdf
Size
2.42 MB
Format
Adobe PDF
Checksum (MD5)
8311c02e09cebb6815a682f0e5c40550
Author(s)
Huang, Ying-Ying
Sharma, Sulbha K.
Dai, Tianhong
Chung, Hoon
Yaroslavsky, Anastasia
Garcia-Diaz, Maria
Chang, Julie
Chiang, Long Y.
Hamblin, Michael R
Date Issued
March 2012
Journal
Nanotechnology Reviews
Publisher
Walter de Gruyter
Citation
Huang, Ying-Ying et al. “Can Nanotechnology Potentiate Photodynamic Therapy?” Nanotechnology Reviews 1.2 (2012): n. pag. © 2012 Walter de Gruyter
Version
Final published version
Abstract
Photodynamic therapy (PDT) uses the combination of nontoxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposomes, lipoplexes, nanoemulsions, micelles, polymer nanoparticles (degradable and nondegradable), and silica nanoparticles. In some cases (fullerenes and quantum dots), the actual nanoparticle itself is the PS. Targeting ligands such as antibodies and peptides can be used to increase specificity. Gold and silver nanoparticles can provide plasmonic enhancement of PDT. Two-photon excitation or optical upconversion can be used instead of one-photon excitation to increase tissue penetration at longer wavelengths. Finally, after sections on in vivo studies and nanotoxicology, we attempt to answer the title question, “can nanotechnology potentiate PDT?”
MIT Department
Institute for Medical Engineering and Science
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1515/ntrev-2011-0005
