Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation
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Author(s)
Merok, Joshua R.
Sherley, James L.
Date Issued
2001
Journal
Journal of Biomedicine and Biotechnology
Publisher
Hindawi Publishing Corporation
Citation
Merok, Joshua R., and James L. Sherley. “Breaching the Kinetic Barrier to in Vitro Somatic Stem Cell Propagation.” Journal of Biomedicine and Biotechnology 1, no. 1 (2001): 25–27. © 2001 Hindawi Publishing Corporation
Version
Final published version
Abstract
Here we have reviewed the conventional definitions and fundamental characteristics of the two basic types of stem cells, embryonic stem cells (ESCs) and somatic stem cells (SSCs). By taking into account the often-overlooked asymmetric cell kinetics of SSCs, we consider the evidence that should SSCs retain these growth kinetics in vitro, a natural kinetic barrier to SSC propagation exists. Recent discoveries showing that the tumor suppressor gene p53 can act as a regulator of asymmetric cell kinetics provide a target pathway for in vitro SSC propagation strategies.
MIT Department
Massachusetts Institute of Technology. Center for Environmental Health Sciences
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DOI of Published Version
https://doi.org/10.1155/S1110724301000067
