Image-guided neural activity manipulation with a paramagnetic drug
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s41467-019-13933-5.pdf
Description
Published version
Size
3.22 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Bricault, Sarah Jean
Barandov, Ali
Harvey, Peter
DeTienne, Elizabeth
Hai, Aviad
Jasanoff, Alan Pradip
Date Issued
January 2020
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Citation
Bricault, Sarah et al. “Image-guided neural activity manipulation with a paramagnetic drug.” Nature Communications, vol. 11, 2020, article 136 © 2020 The Author(s)
Version
Final published version
Abstract
Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Nuclear Science and Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1038/s41467-019-13933-5
