Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery
Name
sciadv.abk1792.pdf
Description
Published version
Size
8.82 MB
Format
Adobe PDF
Checksum (MD5)
9115feba4dc6ab825c8f12b4004c9041
Author(s)
Chen, Wei
Wainer, Jacob
Ryoo, Si Won
Qi, Xiaoyue
Chang, Rong
Li, Jason
Lee, Seung Ho
Min, Seokkee
Wentworth, Adam
Collins, Joy E.
Date Issued
January 7, 2022
Journal
Science Advances
Publisher
American Association for the Advancement of Science
Citation
Wei Chen et al. ,Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery.Sci. Adv.8,eabk1792(2022).
Version
Final published version
Abstract
Oral drug administration remains the preferred route for patients and health care providers. Delivery of macromolecules through this route remains challenging because of limitations imposed by the transport across the gastrointestinal epithelium and the dynamic and degradative environment. Here, we present the development of a delivery system that combines physical (microneedle) and nonphysical (enhancer) modes of drug delivery enhancement for a macromolecule in a large animal model. Inspired by the thorny-headed intestinal worm, we report a dynamic omnidirectional mucoadhesive microneedle system capable of prolonged gastric mucosa fixation. Moreover, we incorporate sodium N-[8-(2-hydroxybenzoyl) amino] caprylate along with semaglutide and demonstrate enhanced absorption in swine resistant to physical displacement in the gastric cavity. Meanwhile, we developed a targeted capsule system capable of deploying intact microneedle-containing systems. These systems stand to enable the delivery of a range of drugs through the generation and maintenance of a privileged region in the gastrointestinal tract.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Division of Comparative Medicine
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1126/sciadv.abk1792
