Hydrogels for RNA delivery
Name
nihms-1885819.pdf
Description
Accepted version
Size
1.63 MB
Format
Adobe PDF
Checksum (MD5)
e458a6e40ff046ef4196382322743ac5
Author(s)
Zhong, Ruibo
Talebian, Sepehr
Mendes, Bárbara B
Wallace, Gordon
Langer, Robert
Conde, João
Shi, Jinjun
Date Issued
March 20, 2023
Journal
Nature Materials
Publisher
Springer Science and Business Media LLC
Citation
Zhong, R., Talebian, S., Mendes, B.B. et al. Hydrogels for RNA delivery. Nat. Mater. 22, 818–831 (2023).
Version
Author's final manuscript
Abstract
RNA-based therapeutics have shown tremendous promise in disease intervention at the genetic level, and some have been approved for clinical use, including the recent COVID-19 messenger RNA vaccines. The clinical success of RNA therapy is largely dependent on the use of chemical modification, ligand conjugation or non-viral nanoparticles to improve RNA stability and facilitate intracellular delivery. Unlike molecular-level or nanoscale approaches, macroscopic hydrogels are soft, water-swollen three-dimensional structures that possess remarkable features such as biodegradability, tunable physiochemical properties and injectability, and recently they have attracted enormous attention for use in RNA therapy. Specifically, hydrogels can be engineered to exert precise spatiotemporal control over the release of RNA therapeutics, potentially minimizing systemic toxicity and enhancing in vivo efficacy. This Review provides a comprehensive overview of hydrogel loading of RNAs and hydrogel design for controlled release, highlights their biomedical applications and offers our perspectives on the opportunities and challenges in this exciting field of RNA delivery.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-ShareAlike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/s41563-023-01472-w
