Striosome–dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons
Name
PNAS-2016-Crittenden-11318-23.pdf
Size
6.31 MB
Format
Adobe PDF
Checksum (MD5)
98a81731f0838878dd812dc0afa7a66a
Author(s)
Shima, Yasuyuki
Gerfen, Charles R.
Nelson, Sacha B.
Crittenden, Jill R
Tillberg, Paul W.
Riad, Michael
Curry, Jeffrey
Housman, David E
Boyden, Edward
Graybiel, Ann M
Date Issued
September 2016
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Crittenden, Jill R. et al. “Striosome–dendron Bouquets Highlight a Unique Striatonigral Circuit Targeting Dopamine-Containing Neurons.” Proceedings of the National Academy of Sciences 113, 40 (September 2016): 11318–11323. © 2016 National Academy of Sciences
Version
Author's final manuscript
Abstract
The dopamine systems of the brain powerfully influence movement and motivation. We demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet-like arborizations that target bundles of ventrally extending dopamine-containing dendrites and clusters of their parent nigral cell bodies. Retrograde tracing showed that these clustered cell bodies in turn project to the striatum as part of the classic nigrostriatal pathway. Thus, these striosome-dendron formations, here termed "striosome-dendron bouquets," likely represent subsystems with the nigro-striato-nigral loop that are affected in human disorders including Parkinson's disease. Within the bouquets, expansion microscopy resolved many individual striosomal fibers tightly intertwined with the dopamine-containing dendrites and also with afferents labeled by glutamatergic, GABAergic, and cholinergic markers and markers for astrocytic cells and fibers and connexin 43 puncta. We suggest that the striosome-dendron bouquets form specialized integrative units within the dopamine-containing nigral system. Given evidence that striosomes receive input from cortical regions related to the control of mood and motivation and that they link functionally to reinforcement and decision-making, the striosome-dendron bouquets could be critical to dopamine-related function in health and disease.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Media Laboratory
McGovern Institute for Brain Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1073/PNAS.1613337113
