Cellulose-Based Fibrous Materials From Bacteria to Repair Tympanic Membrane Perforations
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fbioe-09-669863.pdf
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1.71 MB
Format
Adobe PDF
Checksum (MD5)
1d858f75e860af845bd561d9e10f8334
Author(s)
Azimi, Bahareh
Milazzo, Mario
Danti, Serena
Date Issued
June 2021
Journal
Frontiers in Bioengineering and Biotechnology
Publisher
Frontiers Media SA
Citation
Azimi, Bahareh et al. "Cellulose-Based Fibrous Materials From Bacteria to Repair Tympanic Membrane Perforations." Frontiers in Bioengineering and Biotechnology 9 (June 2021): 669863. © 2021 Azimi, Milazzo and Danti
Version
Final published version
Abstract
Perforation is the most common illness of the tympanic membrane (TM), which is commonly treated with surgical procedures. The success rate of the treatment could be improved by novel bioengineering approaches. In fact, a successful restoration of a damaged TM needs a supporting biomaterial or scaffold able to meet mechano-acoustic properties similar to those of the native TM, along with optimal biocompatibility. Traditionally, a large number of biological-based materials, including paper, silk, Gelfoam®, hyaluronic acid, collagen, and chitosan, have been used for TM repair. A novel biopolymer with promising features for tissue engineering applications is cellulose. It is a highly biocompatible, mechanically and chemically strong polysaccharide, abundant in the environment, with the ability to promote cellular growth and differentiation. Bacterial cellulose (BC), in particular, is produced by microorganisms as a nanofibrous three-dimensional structure of highly pure cellulose, which has thus become a popular graft material for wound healing due to a number of remarkable properties, such as water retention, elasticity, mechanical strength, thermal stability, and transparency. This review paper provides a comprehensive overview of the current experimental studies of BC, focusing on the application of BC patches in the treatment of TM perforations. In addition, computational approaches to model cellulose and TM are summarized, with the aim to synergize the available tools toward the best design and exploitation of BC patches and scaffolds for TM repair and regeneration.
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fbioe.2021.669863
