Diverse intracellular pathogens activate type III interferon expression from peroxisomes
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Gehrke_Diverse intracellular.pdf
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Author(s)
Odendall, Charlotte
Dixit, Evelyn
Stavru, Fabrizia
Bierne, Helene
Franz, Kate M
Boulant, Steeve
Gehrke, Lee
Cossart, Pascale
Kagan, Jonathan C
Durbin, Ann F
Date Issued
August 2014
Journal
Nature Immunology
Publisher
Nature Publishing Group
Citation
Odendall, Charlotte, Evelyn Dixit, Fabrizia Stavru, Helene Bierne, Kate M. Franz, Ann Fiegen Durbin, Steeve Boulant, Lee Gehrke, Pascale Cossart, and Jonathan C. Kagan. “Diverse Intracellular Pathogens Activate Type III Interferon Expression from Peroxisomes.” Nat Immunol 15, no. 8 (June 22, 2014): 717–726.
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Author's final manuscript
Abstract
Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons. The mechanisms controlling type I interferon–independent responses are undefined. We found that RIG-I like receptors (RLRs) induce type III interferon expression in a variety of human cell types, and identified factors that differentially regulate expression of type I and type III interferons. We identified peroxisomes as a primary site of initiation of type III interferon expression, and revealed that the process of intestinal epithelial cell differentiation upregulates peroxisome biogenesis and promotes robust type III interferon responses in human cells. These findings highlight the importance of different intracellular organelles in specific innate immune responses.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
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DOI of Published Version
https://doi.org/10.1038/ni.2915
