Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast
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Amon_Gametogenesis eliminates.pdf
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2.21 MB
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Author(s)
Kinde, B.
Unal, Elcin
Amon, Angelika B
Date Issued
June 2011
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Unal, E., B. Kinde, and A. Amon. “Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast.” Science 332, no. 6037 (June 23, 2011): 1554–1557.
Version
Author's final manuscript
Abstract
Eukaryotic organisms age, yet detrimental age-associated traits are not passed on to progeny. How life span is reset from one generation to the next is not known. We show that in budding yeast resetting of life span occurs during gametogenesis. Gametes (spores) generated by aged cells show the same replicative potential as gametes generated by young cells. Age-associated damage is no longer detectable in mature gametes. Furthermore, transient induction of a transcription factor essential for later stages of gametogenesis extends the replicative life span of aged cells. Our results indicate that gamete formation brings about rejuvenation by eliminating age-induced cellular damage.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1126/science.1204349
