Genetic Evidence for Recent Population Mixture in India
Name
Berger_Genetic evidence.pdf
Size
891.29 KB
Format
Adobe PDF
Checksum (MD5)
b54d9c9ed0efa0ba0912eba408c08373
Author(s)
Moorjani, Priya
Thangaraj, Kumarasamy
Patterson, Nick
Lipson, Mark
Loh, Po-Ru
Govindaraj, Periyasamy
Berger, Bonnie
Reich, David
Singh, Lalji
Date Issued
August 2013
Journal
The American Journal of Human Genetics
Publisher
Elsevier
Citation
Moorjani, Priya, Kumarasamy Thangaraj, Nick Patterson, Mark Lipson, Po-Ru Loh, Periyasamy Govindaraj, Bonnie Berger, David Reich, and Lalji Singh. “Genetic Evidence for Recent Population Mixture in India.” The American Journal of Human Genetics 93, no. 3 (September 2013): 422–438. © 2013 The American Society of Human Genetics
Version
Final published version
Abstract
Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) not closely related to groups outside the subcontinent. The date of mixture is unknown but has implications for understanding Indian history. We report genome-wide data from 73 groups from the Indian subcontinent and analyze linkage disequilibrium to estimate ANI-ASI mixture dates ranging from about 1,900 to 4,200 years ago. In a subset of groups, 100% of the mixture is consistent with having occurred during this period. These results show that India experienced a demographic transformation several thousand years ago, from a region in which major population mixture was common to one in which mixture even between closely related groups became rare because of a shift to endogamy.
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Mathematics
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.ajhg.2013.07.006
