Anisotropic light scattering of individual sickle red blood cells
Name
Kim-2012-Anisotropic light sc.pdf
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1.5 MB
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Author(s)
Kim, Youngchan
Higgins, John M.
Dasari, Ramachandra Rao
Suresh, Subra
Park, YongKeun
Date Issued
April 2012
Journal
Journal of Biomedical Optics
Publisher
SPIE
Citation
Kim, Youngchan et al. “Anisotropic Light Scattering of Individual Sickle Red Blood Cells.” Journal of Biomedical Optics 17.4 (2012): 040501. © 2012 Society of Photo-Optical Instrumentation Engineers
Version
Final published version
Abstract
We present the anisotropic light scattering of individual red blood cells (RBCs) from a patient with sickle cell disease (SCD). To measure light scattering spectra along two independent axes of elongated-shaped sickle RBCs with arbitrary orientation, we introduce the anisotropic Fourier transform light scattering (aFTLS) technique and measured both the static and dynamic anisotropic light scattering. We observed strong anisotropy in light scattering patterns of elongated-shaped sickle RBCs along its major axes using static aFTLS. Dynamic aFTLS analysis reveals the significantly altered biophysical properties in individual sickle RBCs. These results provide evidence that effective viscosity and elasticity of sickle RBCs are significantly different from those of the healthy RBCs.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Spectroscopy Laboratory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1117/1.jbo.17.4.040501
