The Role of miRNAs in Regulating Gene Expression Networks
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Sharp_The Role of.pdf
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Author(s)
Sharp, Phillip A.
Gurtan, Allan
Date Issued
October 2013
Journal
Journal of Molecular Biology
Publisher
Elsevier
Citation
Gurtan, Allan M., and Phillip A. Sharp. “The Role of miRNAs in Regulating Gene Expression Networks.” Journal of Molecular Biology 425, no. 19 (October 2013): 3582–3600.
Version
Author's final manuscript
Abstract
MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across species, expressed across cell types, and active against a large proportion of the transcriptome. The sequence-complementary mechanism of miRNA activity exploits combinatorial diversity, a property conducive to network-wide regulation of gene expression, and functional evidence supporting this hypothesized systems-level role has steadily begun to accumulate. The emerging models are exciting and will yield deep insight into the regulatory architecture of biology. However, because of the technical challenges facing the network-based study of miRNAs, many gaps remain. Here, we review mammalian miRNAs by describing recent advances in understanding their molecular activity and network-wide function.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.jmb.2013.03.007
