The Ups and Downs of the Striatum: Dopamine Biases Upstate Balance of Striosomes and Matrix
Name
Graybiel and Matsushima (2020) Neuron.pdf
Description
Accepted version
Size
305.38 KB
Format
Unknown
Checksum (MD5)
2315b52c3280320e12f0dce72348c29f
Author(s)
Graybiel, Ann M
Matsushima, Ayano
Date Issued
2020
Journal
Neuron
Publisher
Elsevier BV
Citation
Graybiel, Ann M and Matsushima, Ayano. 2020. "The Ups and Downs of the Striatum: Dopamine Biases Upstate Balance of Striosomes and Matrix." Neuron, 108 (6).
Version
Author's final manuscript
Abstract
© 2020 Elsevier Inc. Prager et al. demonstrate an opposite regulation of activity in striosomes and matrix of the striatum. By a D1-receptor-linked L-VGCC-dependent mechanism, dopamine release can extend upstates in matrix D1-expressing projection neurons (dSPNs) but shorten them in striosomal dSPNs.
MIT Department
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.NEURON.2020.11.025
