Nutrients versus growth factors in mTORC1 activation
Name
Sabatini_Nutrients and.pdf
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34.33 KB
Format
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Checksum (MD5)
07f154c7456267355d5ff4d7c209a3d3
Author(s)
Efeyan, Alejo
Sabatini, David M.
Sabatini, David
Alternative Title
Nutrients and growth factors in mTORC1 activation
Date Issued
August 2013
Journal
Biochemical Society Transactions
Publisher
Portland Press
Citation
Efeyan, Alejo, and David M. Sabatini. “Nutrients and Growth Factors in mTORC1 Activation.” Biochem. Soc. Trans. 41, no. 4 (July 18, 2013): 902–905.
Version
Author's final manuscript
Abstract
Growth factors and nutrients regulate the mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] by different mechanisms. The players that link growth factors and mTORC1 activation have been known for several years and mouse models have validated its relevance for human physiology and disease. In contrast with the picture for growth factor signalling, the means by which nutrient availability leads to mTORC1 activation have remained elusive until recently, with the discovery of the Rag GTPases upstream of mTORC1. The Rag GTPases recruit mTORC1 to the outer lysosomal surface, where growth factor signalling and nutrient signalling converge on mTORC1 activation. A mouse model of constitutive RagA activity has revealed qualitative differences between growth-factor- and nutrient-dependent regulation of mTORC1. Regulation of mTORC1 activity by the Rag GTPases in vivo is key for enduring early neonatal starvation, showing its importance for mammalian physiology.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1042/bst20130063
