Sequence of the RAG1 and RAG2 Intergenic Region in Zebrafish (Danio rerio)
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CDI.1998.096749.pdf
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Author(s)
Bertrand III, F. E.
Olson, S. L.
Willett, C. E.
Wu, G. E.
Date Issued
1998
Journal
Developmental Immunology
Publisher
Hindawi Publishing Corporation
Citation
Bertrand III, F. E., S. L. Olson, C. E. Willett, and G. E. Wu. “Sequence of the RAG1 and RAG2 Intergenic Region in Zebrafish (Danio Rerio).” Developmental Immunology 5, no. 3 (1998): 211–214. © 1998 Hindawi Publishing Corporation
Version
Final published version
Abstract
The recombination activating genes, rag1 and rag2 are essential for the rearrangement of antigen receptor V, D, and J gene segments (Oettinger et al., 1990, Mombaerts et al., 1992; Sehatz and Oettinger, 1992; Shinkai et al., 1992). Both genes are found in all species that are known to rearrange their antigenspecific receptors. The coding regions as well as the genomic organization of the rag locus are highly conserved throughout evolution. Rag1 and rag2, which are convergently transcribed, are separated by an intergenic region of DNA that varies in size among species, being, for example, about 11 kb in the human (Homo sapiens), 8 kb in the mouse (Mus musculus), 5.2 kb in the frog (Xenopus laevis), 2.8 kb in the rainbow trout (Oncorhynchus mykiss) (Oettinger et al., 1990; Ichicara et al., 1992; Greenhalgh et al., 1993; Greenhalgh and Steiner., 1995; Hansen and Kaattari, 1996), and 2.6 kb in the zebrafish (Danio rerio).
MIT Department
Massachusetts Institute of Technology. Department of Biology
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DOI of Published Version
https://doi.org/10.1155/1998/96749
