Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model
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13346_2013_Article_190.pdf
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Author(s)
Wood, Joseph
Wang, Ying-Ying
Zeng, Qi
Simons, Brian W
Fu, Jie
Chuang, Chi-Mu
Lai, Samuel K
Wu, T.-C.
Hung, Chien-Fu
Hanes, Justin
Date Issued
January 2014
Journal
Drug Delivery and Translational Research
Publisher
Springer US
Citation
Yang, Ming et al. “Intraperitoneal Delivery of Paclitaxel by Poly(ether-Anhydride) Microspheres Effectively Suppresses Tumor Growth in a Murine Metastatic Ovarian Cancer Model.” Drug Delivery and Translational Research 4.2 (2014): 203–209.
Version
Author's final manuscript
Abstract
Intraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed paclitaxel (PTX)-loaded microspheres composed of di-block copolymers of poly(ethylene glycol) and poly(sebacic acid) (PEG-PSA) for safe and sustained IP chemotherapy. PEG-PSA microspheres provided efficient loading (∼13 % w/w) and prolonged release (∼13 days) of PTX. In a murine ovarian cancer model, a single dose of IP PTX/PEG-PSA particles effectively suppressed tumor growth for more than 40 days and extended the median survival time to 75 days compared to treatments with Taxol® (47 days) or IP placebo particles (34 days). IP PTX/PEG-PSA was well tolerated with only minimal to mild inflammation. Our findings support PTX/PEG-PSA microspheres as a promising drug delivery platform for IP therapy of ovarian cancer and potentially other metastatic peritoneal cancers.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s13346-013-0190-7
